Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-03-10
2000-10-31
Ketter, James
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, C07H 2102
Patent
active
061404845
ABSTRACT:
Bax-.omega. polynucleotides and polypeptides, and compositions effective to hybridize to Bax-.omega. polynucleotides are disclosed. Also disclosed are methods for altering apoptosis in cells, for promoting cell survival and for identifying compounds capable of affecting the binding of Bax-.omega. to other proteins involved in apoptosis.
REFERENCES:
Matsubara et al. 1995. WPI data base, abstract, Derwent Publications, Ltd. London.
Barr, P.J., and L.D. Tomei, "Apoptosis and Its Role in Human Disease," Bio/Technology 12: 487-493 (1994).
Boel, E., et al., "Calcium Binding in .alpha.-Amylases: An X-ray Diffraction Study at 2.1-.ANG. Resolution of Two Enzymes from Aspergillus" Biochemistry 29:6244-6249 (1990).
Boise, Lawrence H., et al., "bcl-x, a bcl-2-Related Gene That Functions as a Dominary Regulator of Apoptotic Cell Death" Cell 74:597-608 (Aug. 27, 1993).
Chittenden, T., et al., "Induction of apoptosis by the Bcl-2 homologue Bak," Nature 374: 733-736 (1995).
Cory, S., "Regulation of Lymphocyte Survival By the BCL-2 Gene Family," Annu. Rev. Immunol. 13: 513-543 (1995).
Farrow, S.N., et al., "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K," Nature 374: 731-733 (1995).
Fisher, D.E., "Apoptosis in Cancer Therapy: Crossing the Threshold," Cell 78: 539-542 (1994).
Gagliardini, V., et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene," Science 263: 826-828 (1994).
Garcia, I., et al., "Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene," Science 258: 302-304 (1992).
Hockenbery, D., et al., "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death," Nature 348: 334-336 (1990).
Jacobson, M.D., and M.C. Raff, "Programmed cell death and Bcl-2 protection in very low oxygen," Nature 374: 814-816 (1995).
Kiefer, M.C., et al., "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak," Nature 374: 736-739 (1995).
Matsubara, K. and Okubo, K., "Identifying Gene Signatures in 3"-Directed Human cDNA Library, e.g. for Diagnosis of Abnormal Cell Function, by Preparing cDNA That Reflects Relative Abundance of Corresponding mRNA Specific Human Tissue", Database WPI, Section Ch, Week 9527, Derwent Publications Ltd., London, GB (abstract), 1995.
Oltvai, Z.N., et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programed Cell Death," Cell 74: 609-619 (1993).
Raff, Martin C., et al., "Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System," Science 262: 695-700 (1993).
Sedlak, T.W., et al., "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax," Proc. Natl. Acad. Sci. USA 92: 7834-7838 (1995).
Shimizu, S., et al., "Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL," Nature 374: 811-813 (1995).
Yin, X-M., et al., "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax," Nature 369: 321-323. (1994).
Bitler Catherine Mastroni
Bowersox Stephen Scott
Crea Roberto
Demo Susan Dunham
Horne William A.
Dehlinger Peter J.
Elan Pharmaceuticals Inc.
Gorthey LeeAnn
Ketter James
Yucel Iram
LandOfFree
Bax .omega. protein and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bax .omega. protein and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bax .omega. protein and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2053469