Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-07-15
2000-10-10
Spector, Lorraine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530326, 530327, 530328, 530329, 435 71, 435 78, 435 691, C07K 14435
Patent
active
061303178
ABSTRACT:
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5, respectively), portions of such nucleic acid molecules, vectors containing the nucleic acid molecules, and host cells containing the vectors. The invention also provides methods of using such nucleic acid molecules to identify the presence of a nucleic acid molecule encoding a Bax inhibitor protein in a sample or to increase or decrease the level of expression of a Bax inhibitor protein in a cell. In addition, the invention provides substantially purified BI-1 (SEQ ID NO: 3) and BI-2 (SEQ ID NO: 6) polypeptides, portions of such polypeptides, and antibodies specific for BI-1 or BI-2. The invention also provides methods of using a BI-1 or BI-2 polypeptide, or a peptide portion thereof, to identify the presence of a member of the Bcl-2 family of proteins in a sample. The invention further provides methods of identifying agents that can modulate the binding of BI-1 or BI-2 to a Bcl-2 family protein, or that can modulate the function of BI-1 or BI-2, irrespective of its ability to bind a Bcl-2 family protein.
REFERENCES:
GenBank accession N28421.
GenBank accession X75861.
Walter et al., "Identification of a Novel Conserved Human Gene, TEGT," Genomics 28:301-304 (1995).
Walter et al., "A novel, conserved gene of the rat that is developmentally regulated in the testis," Mammalian Genome 5:216-221 (1994).
Xu and Reed, "A yeast genetics approach to cloning Bax-suppressors," Proceedings of the Am. Assoc. for Cancer Res. 38;344 (1997).
Tissot et al., Journal of Biological Chemistry 270 (25): 14891-8, Jun. 1995.
Tsugu et al., Genomics 24:541-8, 1994.
Reddy et al., Dev. Biol. 148: 107-116, Nov. 1991.
Reed John C.
Xu Qunli
Lazar-Wesley Eliane
Spector Lorraine
The Burnham Institute
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