Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-06-15
1995-11-28
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530300, 530350, A61K 3802, C07K 200
Patent
active
054708257
ABSTRACT:
Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are useful as diagnostics for, and treatments for, pathologies involving inflammatory and IgE-mediated responses, parasitic and helminthic infections, hypersensitivity reactions and certain types of leukocytic leukemias.
REFERENCES:
patent: 4935370 (1990-06-01), Franke
Denburg et al., "Partial Separation and Functional Characterization of Guinea Pig Basophil-Stimulating Factor," Int. Arch. Allergy Appl. Immunol. (1986) 79(3):312-319.
Wasmoen et al, "Biochemical and Amino Acid Sequence Analysis of Human Eosinophil Granule Major Basic Protein," J. Biol. Chem. (1988) 263:12559-12561.
Geysen et al., "Use of Peptide Synthesis to Probe Viral Antigens for Epitopes to a Resolution of a Single Amino Acid," Proc. Natl. Acad. Sci. (USA) (1984) 81:3998-4002.
Stockinger et al. (1990) Blood 75:1820-1826.
Denburg et al. (1986) Biological Abstracts 81:Abst. 100863.
Dvorak et al. (1977) J. Immunology 119:38-46.
Ackerman et al. (1983) J. Exp. Med. 158:946-961.
Dvorak et al. (1989) Lab. Investigations 60:557-567.
Wasmoen et al. (1981) Proc. Nat. Acad. Sci., USA, 263: 12559-12561.
Blom et al. (1993) Scand. J. Immunol. 37:203-208.
Weller et al. (1984) J. Biol. Chem. 259: 15100-15105.
Abu-Ghazaleh (1992) J. Leucocyte Biol. 52:611-618.
Ackerman et al. (1993) J. Immunol. 150:465-468.
Durack et al. (1981) Proc. Nat. Acad. Sci., USA, 78:5165-5169.
Denburg et al. (1985) Blood 66:312-318.
Galli et al., Prog. Allergy (1984) 34:1-142.
Brown et al., J. Immunol. (1982) 129:790-796.
Ogilvie et al., Immunol. (1980) 39:385-389.
Juhlin et al., Lancet (1977) 1:1233-1235.
Schwartz et al., Immunological Diseases, Samter et al. (eds.), Little Brown & Co. 4th ed., pp. 157-201 (1988).
Solley et al., J. Clin. Invest. (1976) 58:408-420.
Charlesworth et al., J. Clin. Invest. (1989) 83:1519-1526.
Dvorak et al., J. Immunol. (1974) 113:1694-1702.
Orenstein et al., J. Immunol. (1978) 121:586-592.
Ackerman et al., J. Exp. Med. (1982) 155:1597-1609.
Castells et al., J. Immunol. (1987) 138:2184-2189.
Newball et al., J. Clin. Invest. (1979) 64:466-475.
Gleich Gerald J.
Scott Randy W.
Wilde Craig G.
Bozicevic Karl
Bugaisky Gabriele E.
Francis Carol L.
Incyte Pharmaceuticals Inc.
Wax Robert A.
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