Basically-substituted benzoylguanidines, a process for preparing

Details Basically-substituted benzoylguanidines, a process for preparing Basically-substituted benzoylguanidines, a process for preparing

1997-07-30

2000-05-02

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142382, 514312, 514331, 514351, 514392, 514398, 514428, 514399, 514607, 514616, 514618, 514620, 514821, 514866, 514921, 544160, 544400, 544502, 546136, 546157, 546231, 546300, 5483064, 5483415, 5483461, 548566, 564 86, 564101, 564133, 564134, 564139, 564142, 564162, 564154, 564165, A61K 3118, A61K 31165, A61K 3147, A61K 31445

Patent

active

060573228

ABSTRACT:
Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also described.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe, Jr. et al.
patent: 5091394 (1992-02-01), Englert et al.
Duff et al., "Amiloride Antiarrhytmic and Electrophysiologic Actions in Patients With Inducible Sustained Ventricular Tachycardia", Circulation, 79(6): 1257-1263 (1989).
Schomig et al., "Inhibition of Na .sup.30 /H Exchange Suppresses Noradrenaline Release and Arrhythmias In The Ischemic Rat Heart", Eur. Heart J., 9 (suppl. 1): 167 (1988) Book of Abstracts.

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