Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-11-21
1986-08-05
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
2601125R, 530315, C07K 716, A61K 3734
Patent
active
046043780
ABSTRACT:
Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
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M. Manning et al., J. Med. Chem., 20, 1228 (1977).
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Derwent Abstract of European Patent No. 112,809-A.
M. Manning et al., J. Med. Chem., 25, 408-414 (1982).
Peptides: Chemistry, Structure and Biology (Ann Arbor Sciences) 737 (1975).
Callahan James F.
Huffman William F.
Moore Michael L.
Yim Nelson C.
Edgerton William H.
Lourie Alan D.
Moezie F. T.
Phillips Delbert R.
SmithKline Beckman Corporation
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