Basic protein phospholiphase A2

Details Basic protein phospholiphase A2 Basic protein phospholiphase A2

1991-02-11

1992-11-17

Ellis, Joan

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 920

Patent

active

051643154

ABSTRACT:
The present invention relates to a basic protein called phospholipase A2 (PLA2), isolated from the venom of a snake of the family Elapidae, especially of a Naja snake and more particularly Naja nigricollis and/or Naja mossambica pallida, to the fragments and derivatives of the said protein, to their methods of preparation, to pharmaceutical compositions which can be used to human and/or veterinary medicine, and to diagnostic agents in which the said protein and/or its derivatives and/or its fragments are present.
The said protein comprises 118 amino acids, its molecular weight is of the order of 13,300 Daltons and its isoelectric point is of the order of 8.6.
The derivatives of the said protein are modified at one of the histidines by fixation of an alkyl group of the formula R--CH.sub.2 --X.
Application to the detection of tumoral cells.

REFERENCES:
Joubert, Biochimica and Biophysra Acta, 493, pp. 216-227 (1977).
J. B. Harris, Snake Toxins, Ch. 3 pp. 91-129, A. L. Harvey, Ed. 1991 Pergamon Press, Inc.

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