Food or edible material: processes – compositions – and products – Processes – Separating a starting material into plural different...
Patent
1997-01-21
1999-11-02
Eisenschenk, Frank C.
Food or edible material: processes, compositions, and products
Processes
Separating a starting material into plural different...
426271, 426580, 426587, 426588, 426590, 514773, 514775, A23C 100, A23C 704, A23C 9146, A23C 914
Patent
active
059765976
ABSTRACT:
The present invention provides a basic protein and a basic peptide composition which can be administered orally and has the ability to stimulate osteoblast proliferation, strengthen bone and inhibit bone resorption. Said basic protein has the following properties: (1) a molecular weight distribution of is 2,000-24,000; (2) an isoelectric point distribution of is 7.5-11; and (3) it is comprised of more than 10% of basic amino acids. Said composition can be obtained by the following steps: After milk, or raw material derived from milk, is loaded onto a cation exchange resin column, a fraction is obtained by eluting with an eluent of 0.1-1.0M salt concentration, precipitate removed by (i) heating to over 75.degree. C., (ii) by adding alcohol so that the final concentration thereof is 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatant thereof containing the basic protein fraction recovered.
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Database WPI, Section Ch, Week 9635, "Bone Strengthing Composition for Increasing Calcium Absorption, Osteoporosis--Contains Basic Protein Fraction and Calcium Derived from Milk, Especially Useful for Children," Derwent Publications Ltd., London, GB, Class B04, AN 96-350156, XP-002073914.
Aoe Seiichiro
Kato Ken
Matsuyama Hiroaki
Takada Yukihiro
Yamamura Junichi
Eisenschenk Frank C.
Fujino Patent Attorney
Zeman Mary K
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