Basic protein called phospholipase A2 isolated from the venom of

Details Basic protein called phospholipase A2 isolated from the venom of Basic protein called phospholipase A2 isolated from the venom of

1988-11-17

1991-09-03

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 920

Patent

active

050454625

ABSTRACT:
The present invention relates to a basic protein called phospholipase A2 (PLA2), isolated from the venom of a snake of the family Elapidae, especially of a Naja snake and more particularly Naja nigricollis and/or Naja mossambica pallida, to the fragments and derivatives of the said protein, to their methods of preparation, to pharmaceutical compositions which can be used in human and/or veterinary medicine, and to diagnostic agents in which the said protein and/or its derivatives and/or its fragments are present.
The said protein comprises 118 amino acids, its molecular weight is of the order of 13,300 Daltons and its isoelectric point is of the order of 8.6.
The derivatives of the said protein are modified at one of the histidines by fixation of an alkyl group of the formula R--CH.sub.2 --X.
Application to the detection of tumoral cells.

REFERENCES:
Chwetzoff et al, The Journal of Biological Chemistry, vol. 264, pp. 13289-13297 (1989).
Louw, BBA, 336, pp. 481-496 (1974).
Biological Abstracts, 36(1), Abstract 6703 Chaim-Matyas et al.
Chem. Abstracts, 94, 186580h, Condrea et al (1981).
Fryklund et al, Biochemistry, vol. 14, pp. 2865-2871 (1975).
Joubert, BBA 493 (1977) 216-227, Naja Mossambica Mossambica Venom; Purification, Some Properties & the AA Seq of Three Phospholipases.
Joubert & Taljaard, Eur J Biochem, 112, 493-499 (1980) Purification, Some Properties & AA Seq of 2 Phospholipases A from Naja naja kaouthia Venom.

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