Basic oximes and their preparation

Details Basic oximes and their preparation Basic oximes and their preparation

1971-06-11

1976-11-02

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3115

Patent

active

039898440

ABSTRACT:
Oximes of the formula: ##SPC1##
And their acid salts, wherein A is a branched or unbranched, saturated or unsaturated alkylene chain of 0-6 carbon atoms, B is a basic nitrogen-containing group such as an amino, alkylamino, dialkylamino, cycloalkylamino, dicycloalkylamino, cycloalkylalkylamino, dicycloalkylalkylamino, alkylarylamino, alkylaralkylamino, a piperidino, pyrrolidino, hexamethyleneimino, morpholino, thiomorpholino, N-alkylpiperazino or N-(2-hydroxyalkyl)-piperazino group, n is 1 or 2 and X is --CH.sub.2 --, --(CH.sub.2).sub.3 -- or --CH = CH--, and R.sub.1 and R.sub. 2 are each hydrogen, halogen, alkyl of 1-4 carbon atoms, alkoxy, alkylmercapto groups of 1-4 carbon atoms, hydroxyl, nitro, amino or trifluoromethyl, are useful for their anti-depressant activity. Pharmaceutical compositions may be prepared which comprise an anti-depressant amount of at least one such compound in combination with a pharmaceutically acceptable inert diluent or carrier. Depression in humans and animals may be treated by administering an anti-depressant amount of such an oxime to such human or animal.

REFERENCES:
patent: 3270055 (1966-08-01), Engelhard et al.
patent: 3349128 (1967-10-01), Judd
patent: 3441608 (1969-04-01), Shutz et al.
patent: 3526631 (1970-09-01), Judd
patent: 3526671 (1970-09-01), Judd

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