Basic monocyclic compounds having Nk2 antagonist action,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S018700, C514S217000, C530S317000, C530S330000

Reexamination Certificate

active

07015196

ABSTRACT:
Basic monocyclic compounds having general formula (I) useful as NK-2 antagonists are described, processes for their preparation and pharmaceutical compositions containing them are also described.

REFERENCES:
patent: 033174 (1989-09-01), None
patent: WO9303059 (1993-02-01), None
patent: WO9321227 (1993-10-01), None
patent: WO9717362 (1997-05-01), None
patent: WO9834949 (1998-08-01), None
patent: WO0008046 (2000-02-01), None
Kudiacz et al., “Tachykinin-mediated Respiratory Effects in Conscious Guinea Pigs: Modulation by NK, and NK, Receptor Agonists”,European Journal of Pharmacology, 241, pgs. 17-25 (1993).
McKnight et al., “Pharmacological Specificity of Novel, Synthetic, Cyclic Peptides as Antagonists at Tachykinin Receptors”,J. Pharmacol. 104, 355-360 (1991).
Quartara et al., “Influence of Lipophilicity on the Biological Activity of Cyclic Pseudopeptide NK-2 Receptor Antagonist”,Journal of Medicinal Chemistry, (1994).
Peptides, Chemistry and Biology, Proceedings of the 12th American Peptide Symposium, Jun. 16-21, 1991, Cambridge Mass, Published by Escom (1992).

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