Basic monocarboxyamide derivatives of actagardine having antibio

Details Basic monocarboxyamide derivatives of actagardine having antibio Basic monocarboxyamide derivatives of actagardine having antibio

1986-03-21

1987-08-04

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514222, 514228, 514252, 514255, 514316, 514331, 514422, 514428, 514542, 514550, 514562, 514570, 424117, 544 581, 544 585, 544 586, 544 85, 544111, 544121, 544130, 544141, 544159, 544357, 544359, 544360, 544364, 544372, 544400, 546190, 546208, 546233, 548523, 548567, 548568, 548950, 560 9, 560147, 562426, 562556, A61K 3574, A61K 3500, C07D29514

Patent

active

046846441

ABSTRACT:
The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine. More particularly, they are basic monoamide derivatives of actagardine which may be schematically represented by the following formula I: ##STR2## The compound of the invention possess improved antimicrobial activity in particular against gram positive bacteria.

REFERENCES:
patent: 4022884 (1977-05-01), Parenti et al.
Malabarba et al., Chemical Abstracts, vol. 104, (1986), No. 48401z.

Affiliated with

Also associated with

Rating

Basic monocarboxyamide derivatives of actagardine having antibio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Basic monocarboxyamide derivatives of actagardine having antibio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Basic monocarboxyamide derivatives of actagardine having antibio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-883973