Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-08-28
1985-09-24
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514807, 2601125R, A61K 3700, C07C10352
Patent
active
045433496
ABSTRACT:
Certain cyclic vasopressin-like peptides, which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have vasopressin antagonist activity. A species of this series of new compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-(1,5-diaminopentane)-8-desarginine -9-desglycinamide]-vasopressin.
REFERENCES:
M. Manning, et al., Nature, 308 652 & 653 (1984).
Callahan James F.
Moore Michael L.
Yim Nelson C.
Edgerton William H.
Foggio Richard D.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
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