Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1990-01-08
1992-10-13
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
514 12, 435 694, C07K 1300, A61K 3736
Patent
active
051552140
ABSTRACT:
Substantially pure mammalian basic fibroblast growth factors are produced. The amino acid residue sequences of bovine and human bFGF are disclosed as well as a DNA chain encoding the polypeptide of the bovine species. By appropriately inserting a synthesized DNA chain into a cloning vector and using the cloning vector to transform cells, synthetic bFGF can be obtained from transformed cell lines, both prokaryotic and eukaryotic.
REFERENCES:
patent: 4956455 (1990-09-01), Esch et al.
Gospodarowicz et al., J. Cell Biol. 97: 1677-1685 (1983).
Gospodarowicz et al., J. Biol. Chem., 257: 12266-12276 (1982).
Baird Andrew J.
Bohlen Peter
Esch Frederick S.
Gospodarowicz Denis
Ling Nicholas C.
Guest Shelly
Lacey David L.
The Salk Institute for Biological Studies
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