Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for the

Details Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for the Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for the

1982-09-14

1987-04-28

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

564352, 564353, 564354, C07C 9306

Patent

active

046612971

ABSTRACT:
Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.

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patent: 3892776 (1975-07-01), Hook et al.
patent: 4169897 (1979-10-01), Meyer et al.

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