Base sequence for control probe and method of designing the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S006120, C536S023100, C530S300000, C530S350000

Reexamination Certificate

active

07923546

ABSTRACT:
There are provided a sequence for a control probe having a sequence rarely forming a secondary structure and rarely hybridizing with an undesired target and a method of designing thereof. There is further provided a probe carrier employing a control probe designed by the designing method. To provide these, a palindromic sequence is selected based on a sequence of which frequency is low in a database for a predetermined base sequence and used as the sequence of the control probe.

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Russell Roslin, “Designing microarry oligonucleotide probes”, Briefings in Bioinformatics, vol. 4, No. 4, Dec. 2003, pp. 361-367.

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