Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-12-23
1999-04-06
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 913, 435 6, 4351723, 4353201, 435325, 536 241, 536 245, C07H 2104, C12N 1585, C12N 1500
Patent
active
058916849
ABSTRACT:
Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
Stull, et al "Antigene, Ribozyme and aptomer Nucleic Acid Drugs: Progress & Prospects," Pharmaceutical Research vol. 12 (4) 1995, pp. 465-483.
Bevilaqua et al "Comparison of Binding Mixed Ribose-Deoxycribose Anabgues of CUCU to a Ribozyme and to GGAGAA by Equalibrum Dialysis: Evidence for Ribozymes Specific luteractions with 2'OH Groups." Biochemistry vol. 30 1991 pp. 10632-10640.
Chowrira et al. "Binding Cleavage of Nucleic Acids by the Vairpin Ribozyme," Biochemistry, vol. 30 8518-8522 1991.
Pyle et al "Ribozyme recognition of RNA by Tertiary Interactions with specific ribose 2'OH groups". Nature vol. 350 1991 pp. 628-631.
Fu, et al "Importance of specific Purine amino & hydroxyl groups for efficient cleavage by a hammerhead Ribozyme" PNAS vol. 89 pp. 3985-3989 1992 May.
Haseloff et al, "Simple RNA Ribozymes with now & highly specific eudonuclease activitys" Nature. vol. 334 1988 pp. 585-591.
Perrotta et al "Cleavage of Oligonuzleotides by a Ribozyme Derived from Hepatitis 8 Virus RNA Sequence." Biochemistry. vol. 31 (1) 1992 pp. 16-21.
Guerrier-Takada, "The RNA Moiety of Ribonuclease P is the Catalytic Subunit of the Enzymc" Cell vol. 35 1983 pp. 849-857.
Hanpel et al, Hairpin Catalytic RNA Model: evidence for holices and Sequence requirement for Substrate RNA. NAR vol. 18(2) 1990 pp. 299-304.
Uhlman et al "Antisense Oligonucleotide: A New Therepatic Principle" Chemical Reviews. vol. 90 (4) 1990 pp. 544-584.
Caprara et al., "Important 2'-Hydoxyl Groups Within the Core of a Group I Intron" Biochemistry 32:(14)3604-3610 (1993).
Chowrira et al., "Four Ribose 2'-Hydroxyl Groups Essential for Catalytic Function of the Hairpin Ribozyme" The Journal of Biological Chemistry 268:26 19458-19462 (1993).
Wieczorek et al., "Evidence That Total Substitution of Adenine With 7-Deaza-Adenine in the HDV Antigenomic Ribozyme Changes The Kinetics of RNA Folding" Elsevier Science 987-994 (1994).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
He et al., "In Vitro cleavage of HPV16 E6 and E7 mRNA by designed ribozymes," Chemical Abstracts vol. 120, No. 1 at abstract No. 3342 (1994).
He et al., "In Vitro cleavage of HPV16 E6 and E7 mRNA by designed ribozymes," FEBS Letters 322:21-24 (1993).
Lu et al., "Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16," Cancer Gene Therapy 1(4):267-277 (1994).
Rossi and Sarver, "RNA enzymes (ribozymes) as antiviral therapeutic agents," TIBTECH 8:179-183 (1990).
Rossi et al., "Ribozymes as potential therapeutic agents," Proc. Annu. Meeting Am. Assoc. Cancer Res. 34:592-593 (1993).
Rossi et al., "Ribozymes As Therapies For AIDS," Annals of the New York Academy of Sciences 606:184-200 (1990).
von Weizsacker et al., "Cleavage of Hepatitis B Virus RNA by Three Ribozymes Transcribed Fro a Single DNA Template," Biochemical and Biophysical Research Communications 189:743-748 (1992).
Wong-Staal, "Molecular targets for interference with viral replication," International Conference on AIDS 9(1):10 (1993).
Beigelman Leonid
Karpeisky Alex
McSwiggen James
Usman Nassim
Elliott George C.
McGarry Sean
Ribozyme Pharmaceuticals Inc.
LandOfFree
Base-modified enzymatic nucleic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Base-modified enzymatic nucleic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Base-modified enzymatic nucleic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1370401