Base for coating solid enteric pharmaceutical preparations

Details Base for coating solid enteric pharmaceutical preparations Base for coating solid enteric pharmaceutical preparations

1996-04-29

1997-12-23

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 56, 536 58, 536 63, 536115, 536119, 514963, 514970, 514 47, 424464, 424474, C08B 300, A61K 928

Patent

active

057009295

ABSTRACT:
A coating base for solid enteric pharmaceutical preparations having a dissolution pH ranging from 3.5 to 4.5 essentially consisting of hydroxypropylmethyl cellulose trimellitate obtained by substituting water-soluble hydroxypropylmethyl cellulose having 1.1 to 1.6 methoxy group per glucose ring thereof with 0.2 to 1.0 trimellitate group per glucose ring, or obtained by substituting water-soluble hydroxypropylmethyl cellulose having 1.7 to 2.1 methoxy groups per glucose ring thereof with 0.2 to 0.5 trimellitate group per glucose ring. The coating base can be dissolved at the upper portion of the small intestine without delay and a solid enteric pharmaceutical preparation provided with a coating film of the base can completely release the drug included therein before the preparation passes through the small intestine. Therefore, the base can ensure a high pharmacological action of the drug.

REFERENCES:
patent: 4983401 (1991-01-01), Eichel et al.
Adams, "Influence of Dissolution Media pH on the Release Characteristics of Aspirin Tablets coated using completely dissolved Cellulose Acetate Trimellitate (CAT), and Hydroxypropylmethy cellulose Phthalate (HPMP) Enteric Coating Materials", Pharm. Res. 1990, 7, Suppl., 598) (month not available).
Kane et al., "Technological Evaluation of three Enteric Coating Polymers I. with an Insoluble Drug," Drug Dev. and Industrial Pharm. 1993, 19, 2011-2020, (month not available).

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