Base catalyzed acylation with enol esters

Details Base catalyzed acylation with enol esters Base catalyzed acylation with enol esters

1981-07-10

1982-08-24

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, 26039745, C07J 7100

Patent

active

043460372

ABSTRACT:
This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols including hydroxy steroids.

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Hagemeyer, Jr., et al., "Reactions of Isopropenyl Acetate", Ind. Eng. Chem., vol. 41, No. 12, pp. 2920-2924, (1949).
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Jeffrey, et al., reports in "Part VII The Kinetics and Mechanism of the Enol-Acetylation of Acetophenone by Isopropenyl Acetate Catalysed by Toluene-p-sulphonic Acid", J. Chem. Soc. 1961.
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"Steroid Reactions", by Djerassi, (1963) Holden-Day Inc., San Francisco.

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