Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1995-10-18
1998-02-24
Venkat, Jyothsan
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424443, 514844, 514846, A61K 748
Patent
active
057209634
ABSTRACT:
New topically applied treatments for structurally deteriorated or otherwise aged skin are shown by comparative data to effect structural improvements in the deteriorated skin, as shown by skin-thickening data. The disclosed treatments disrupt the skin's water barrier and elevate trans-epidermal moisture loss (TEML) for extended periods of weeks or months and include methods of mechanical or solvent action, for example, tape stripping, or acetone washes. Preferred treatments use cosmetic creams or gels with active ingredients such as lactic acid as a primary, water-soluble barrier disruption agent, a retinoid, for example vitamin A palmitate as a lipid-soluble barrier disruption agent and a particular cerebroside to inhibit barrier repair. Such novel creams or gels can be applied daily for extended periods to provide chronic, sustained disruption of the barrier as indicated by significantly elevated TEML. Novel cosmetic formulations have particular application to improving the appearance and structure of sensitive facial areas of the skin.
REFERENCES:
patent: 4363815 (1982-12-01), Yu et al.
patent: 5051449 (1991-09-01), Kligman
patent: 5091171 (1992-02-01), Yu et al.
patent: 5190876 (1993-03-01), Merril, Jr. et al.
patent: 5215759 (1993-06-01), Mausner
patent: 5382432 (1995-01-01), McCook
patent: 5391373 (1995-02-01), Mausner
patent: 5401517 (1995-03-01), Meyers et al.
patent: 5422370 (1995-06-01), Yu et al.
patent: 5476661 (1995-12-01), Pillai et al.
patent: 5587396 (1996-12-01), Smith
Imokawa et al. In J. Soc. Cosmet. Chem 40, 273-285, Oct. 1989.
Soap, Cosmetics, Chemical Specialties, vol. 69, No. 2, Feb. 1993, New York, pp. 20-24, "New ingredients and formulations are cropping up in cosmeceuticals and treatment products for the skin".
Merck Index, element edition, Merck & Co., Inc. 1989, monograph number 87.
"Comparison of Methods for Measurement of Transepidermal Water Loss" by A. O. Barel et al, from Non-Invasive Methods and th Skin, pp. 179-184, CRC Press, Boca Raton, Florida 1995.
Mitsushiro Denda, Peter M. Elias et al. "Epidermal injury vs. barrier disruption as initiators of epidermal proliferation and inflammation", from The Journal of Investigative Dermatology, vol. 104, No. 4, p. 563 Abstract No. 46 (Apr. 1995).
Pinnagoda et al. "Measurement of the Transepidermal Water Loss" pp. 173-178, chapter 9.1 from Non-Invasive Methods and the Skin, editors J. Serup and G.B.E. Jemec, CRC Press, Boca Raton, Florida 1995.
Barel et al. "Comparison of Methods for Measurement of Transepidermal Water Loss", chapter 9.2 from Non-Invasive Methods and the Skin, editors J. Serup and G.R.E. Jemec, CRC Press, Boca Raton, Florida 1995.
Proksch et al. in "Barrier function regulates epidermal lipid and DNA synthesis" British Journal of Dermatology (1993) 128, 473-482.
Rieger et al. "Skin Consitutuents as Cosmetic Ingredients' from Cosmetics & Toiletries", vol. 107, pp. 85-94 (Nov. 1992).
Mary Kay Inc.
Venkat Jyothsan
LandOfFree
Barrier disruption treatments for structurally deteriorated skin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Barrier disruption treatments for structurally deteriorated skin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Barrier disruption treatments for structurally deteriorated skin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1873568