Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-11-13
2007-11-13
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S256000, C544S224000, C544S242000, C544S299000
Reexamination Certificate
active
10321144
ABSTRACT:
The present application describes novel barbituric acid derivatives of formula I:or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Zaare defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
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Zalukaev et al., “5-(α-Phenyl-β-aroylethyl)barbituric acids”, Tr. Voronezh. Univ. (1972), 95(2), 50-1, Ref. Zh., Khim., 1972, Abstr. No. 12Zh325. Journal written in Russian (English Abstract attached).
Zalukaev et al., “Reaction of barbituric acid with α,β-unsaturated ketones”, Voronezh. Gos. Univ., Voronezh, USSR, Khimiya Geterotsiklicheskikh Soedinenil, (1971), 7(6), 836-7. CODEN: KGSSAQ ISSN: 0132-6244. Journal written in Russian (English Abstract attached).
Barbosa Joseph
Chen Lihua
Duan Jingwu
Jiang Bin
Lu Zhonghui
Bristol Myers Squibb Company
Sun Jing G.
Ward Paul V.
Wilson James O.
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