Barbituric acid derivatives as inhibitors of TNF-α...

Details Barbituric acid derivatives as inhibitors of TNF-α... Barbituric acid derivatives as inhibitors of TNF-α...

2005-08-30

2005-08-30

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S270000, C544S299000, C544S309000

Reexamination Certificate

active

06936620

ABSTRACT:
The present application describes novel barbituric acid derivatives of formula I:or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, W, Z, Ua, Xa, Ya, and Zaare defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.

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Black, R.A. et al., Chater 24, “Agents that Block TNF-a Synthesis or Activity.” Ann. Rep. Med. Chem., 1997, vol. 32, pp. 241-250.

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