Barbituric acid derivative and treatment of leukemia and tumors

Details Barbituric acid derivative and treatment of leukemia and tumors Barbituric acid derivative and treatment of leukemia and tumors

1988-05-10

1990-04-24

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514908, 544301, A61K 31505, C07D23960

Patent

active

049201263

ABSTRACT:
N-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidinecarbo xamide, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compound has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from hydrogen or a cyclic or acyclic group which forms pyrimidine nucleosides or pseudo nucleosides, and the pharmacologically acceptable acid addition salts thereof.

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