Barbituric acid derivative and treatment of leukemia and tumors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514908, 544301, A61K 31505, C07D23960

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active

049201263

ABSTRACT:
N-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidinecarbo xamide, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compound has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from hydrogen or a cyclic or acyclic group which forms pyrimidine nucleosides or pseudo nucleosides, and the pharmacologically acceptable acid addition salts thereof.

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