Barbituric acid antigens and antibodies specific therefor

Details Barbituric acid antigens and antibodies specific therefor Barbituric acid antigens and antibodies specific therefor

1976-03-23

1978-08-15

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 1, 424 12, 424 85, A61K 3706, C07G 700

Patent

active

041071573

ABSTRACT:
Barbituric acid antigens are prepared by coupling 5- or 5,5-substituted barbituric acid to immunogenic carrier materials. In preferred embodiments, proteins are used as the carrier materials and the coupling is effected by an amide linkage between the 5-substituent of the barbituric acid and a carboxyl or amino group of the protein. The resulting antigens produce immunological effects when injected into host animals, including the formation of antibodies specific for 5- and 5,5-substituted barbituric acids. These specific antibodies are useful in bioanalytical techniques for the assay of barbituric acids in biological fluids.

REFERENCES:
patent: 3690834 (1972-09-01), Goldstein et al.
patent: 3995021 (1976-11-01), Gross
Erlanger et al., J. Biol. Chem. 228, 713-727, (1957).
Erlanger et al., J. Biol. Chem. 234, 1090-1094, (1959).
Belser et al., Science, 129, 564-565 (1959).

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