Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-07-22
1995-12-12
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514270, 514289, 514315, 514318, A61K 3154, A61K 3144, A61K 31445, A61K 31515
Patent
active
054749905
ABSTRACT:
Certain barbiturates have been shown to completely prevent the neurotoxic injury to cerebrocortical neurons that can be caused by NMDA antagonists. The use of barbiturates as "safening agents" allows NMDA antagonists (including powerful NMDA antagonists such as MK-801) to be used safely as neuroprotectants to prevent brain damage due to hypoxia/ischemia caused by strokes, cardiac arrest, perinatal asphyxia, and various other conditions.
REFERENCES:
patent: 3930006 (1975-12-01), Wiggins et al.
patent: 4064139 (1977-12-01), Anderson et al.
patent: 4374838 (1983-02-01), Anderson et al.
patent: 4399141 (1983-08-01), Anderson et al.
patent: 4833148 (1989-05-01), Olney
patent: 4888347 (1989-12-01), Woodruff et al.
Henley III Raymond
Kelly Patrick D.
Weddington K.
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