Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-11-18
2000-05-09
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
536 231, 536 235, C07K 1447, C12U 1512
Patent
active
06060588&
ABSTRACT:
The present invention provides the amino acid and nucleotide sequence of a protein that binds to .beta.3 integrins, .alpha.IIb and Src kinase and is involved in integrin mediated signaling. Based on this disclosure, the present invention provides methods for identifying agents that block integrin mediated signaling, methods of using agents that block integrin mediated signaling to modulate biological and pathological processes, and agents that block integrin mediated signaling.
REFERENCES:
patent: 5192746 (1993-03-01), Lobl et al.
patent: 5260277 (1993-11-01), McKenzie
patent: 5580979 (1996-12-01), Bachovchin
G. Marguerie et al., "Platelet Alpha-IIB-Beta-3: A Pharmacological Integrin As a Target to Design New Molecules with Antithrombotic Activity," J. of Experimental and Clinical Hematology, vol. 35, No. 3, pp. 253-254 (1993).
M.J.S. Dyer et al., "Identification of Novel Ring Finger Genes that Interact with BCL7A," Abstracts of Papers Presented at the Annual Scientific Mtg., of the British Soc. For Haematology, p. 10, Abstract No. 32, (Apr. 14-17, 1997).
J. Schoorlemmer et al., "Ring1A is a Transcriptional Repressor that Interacts with the Polycomb-M33 Protein and is Expressed at Rhombomere Boundaries in the Mouse Hindbrain," The EMBO Journal, vol. 16, No. 19, pp. 5930-5942 (Oct. 1, 1997).
Lovering, R. et al. Proc. Natl. Acad. Sci. USA 90: 2112-2116, Mar. 1993.
Chellaiah, M. Endocrin. 137 (6): 2432-2440, Jun. 1996.
Voet, D. et al., Eds. Biochemistry John Wiley & Sons, New York, NY p. 130, 1990.
Argraves, W. S., et al., Fibulin, a Novel Protein that Interacts with the Fibronectin Receptor .beta. Subunit Cytoplasmic Domain, Cell, vol. 58, pp. 623-629 (1989).
Bartfeld, N.S., et al., The .alpha..sub.v .beta..sub.3 Integrin Associates with a 190-kDa Protein That is Phosphorylated on Tyrosine in Response to Platelet-derived Growth Factor, Journal of Biological Chemistry, vol. 268, pp. 17270-17276 (1993).
Blystone, Scott D., et al., Inducible Tyrosine Phosphorylationof the .beta..sub.3 Integrin Requires the .alpha..sub.v Integrin Cytoplasmic Tail, Journal of Biological Chemistry, pp. 31458-31462 (1996).
Califf, Dr. Robert M. et al., Use of a Monoclonal Antibody Directed Against the Platelet Glycoprotein IIb/IIIa Receptor in High-Risk Coronary Angioplasty, New England Journal of Medicine, vol. 330, pp. 956-961 (1994).
Chen, Y.P., et al., "Inside-out" Signal Transduction Inhibited by Isolated Integrin Cytoplasmic Domains, Journal of Biological Chemistry, vol. 269, pp. 18307-18310 (1994).
Clark et al., Integrins and Signal Transduction Pathways: The Road Taken, Science, vol. 268, pp. 233-239 (1995).
Dedhar S., et al., Integrin cytoplasmic interactions and bidirectional transmembrane signaling, Current Opinion in Cell Biology, vol. 8, pp. 657-669 (1996).
Diamond, Michael S., et al., The Dynamic Regulation of Integrin Adhesiveness, Current Biology, vol. 4, pp. 506-517 (1994).
Faull, Randall J., et al., Dynamic Regulation of Integrins, Stem Cells, vol. 13, pp. 38-46 (1995).
Filardo, Edward J., et al., Requirement of the NPXY Motif in the Integrin .beta.3 Subunit Cytoplasmic Tail for Melanoma Cell Migration in Vitro and In Vivo, Journal of Cell Biology, vol. 130, No. 2, pp. 441-450 (1995).
Findik, Duygu, et al., Platelet Membrane Glycoproteins IIb and IIIa are Substrates of Purified pp60.sup.0-src Protein Tyrosine Kinase, FEBS, vol. 262, No. 1, pp. 1-4 (1990).
Fitzgerald, Laurence A., et al., Protein Sequence of Endothelial Glycoprotein IIIa Derived from a cDNA Clone, Journal of Biological Chemistry, vol. 262, No. 9, pp. 3936-3939 (1987).
Fox, Joan E.B., et al., On the Role of the Platelet Membrane Skeleton in Mediating Signal Transduction, Journal of Biological Chemistry, vol. 268, pp. 25973-25984 (1993).
Ginsberg, M.H., et al., Platelet Integrins, Thrombosis and Haemostasis, vol. 70, pp. 87-93 (1993).
Ginsberg, M.H., et al., Inside-out Integrin Signaling, Current Opinion Cell Biol., vol. 4, pp. 766-771 (1992).
Grinblat, Yevgenya, et al., Functions of the Cytoplasmic Domain of the B.sub.PS Integrin Subunit During Drosophila Development, Development, vol. 120, pp. 91-102 (1994).
Haas, Thomas A., et al., The Cytoplasmic Domains of Platelet Glycoprotein IIb-IIIa (.alpha..sub.IIb .beta..sub.3) Interact in a Cation Dependent Manner, Journal of the International Society on Thrombosis and Haemostasis, vol. 73, No. 6, p. 1190 (1995).
Haimovich et al., Tyrosine Phosphorylation and Cytoskeletal Reorganization in Platelets Are Triggered by Interaction of Integrin Receptors with Their Immobilized Ligands, Journal of Biological Chemistry, vol. 268, pp. 15868-15877 (1993).
Hannigan, Gregory E., et al., Regulation of Cell Adhesion and Anchorage-dependant Growth by a New .beta..sub.1- Integrin-Linked Protein Kinase, Nature, vol. 379, pp. 91-96 (1996).
Hayashi, Yokichi, et al., Expression and Function of Chicken Integrin .beta.1 Subunit and its Cytoplasmic Domain Mutants in Mouse NIH 3T3 Cells, Journal of Cell Biology, vol. 110, pp. 175-184 (1990).
Hibbs, Margaret L., et al., The Cytoplasmic Domain of the Integrin Lymphocyte Function-associated Antigen 1 .beta. Subunit: Sites Required for Binding to Intercellular Adhesion Molecule 1 and the Phorbol Ester-stimulated Phosphorylation Site, J. Exp. Med., vol. 174, pp. 1227-1238 (1991).
Hillery, Cheryl, et al., Phosphorylation of Human Platelet Glycoprotein IIIa (GPIIIa), Journal of Biological Chemistry, Vo. 266, No. 22, pp. 14663-14669 (1991).
Hillier, L.. et al., Wash U. Merck EST Project May 26, 1995 GenBank Accession No. R64408.
Hirsch, E., et al., Impaired migration but not differentiation of haematopoietic stem cells in the absence of .beta..sub.1 integrins, Nature, vol. 380, pp. 171-175 (1996).
Hirst, Roger, et al., Phosphorylation of the Fibronectin Receptor Complex in Cells Transformed by Oncogenes that Encode Tyrosine Kinases, Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6470-6474 (1986).
Horwitz, Alan, et al., Interaction of Plasma Membrane Fibronectin Receptor with Talin--a Transmembrane Linkage, Nature, vol. 320, pp. 531-533 (1986).
Hsu, Hailing, et al., TRADD-TRAF2 and TRADD-FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways, Cell, vol. 84, pp. 299-308 (1996).
Huang, M.M., et al., Adhesive Ligand Binding to Integrin .alpha..sub.IIb .beta..sub.3 Stimulates Tyrosine Phosphorylation of Novel Protein Substrates before Phosphorylation of pp125.sup.FAK, Journal of Cell Biology, vol. 122, pp. 473-483 (1993).
Hughes, P.E., et al., The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity, Journal of Biological Chemistry, vol. 270, pp. 12411-12417 (1995).
Huttenlocher, A., et al., Modulation of Cell Migration by Integrain-mediated Cytoskeletal Linkages and Ligand-binding Affinity, Journal of Cell Biology, vol. 134, pp. 1551-1562 (1996).
Hynes, R.O., Integrins: Versatility, Modulation, and Signaling in Cell Adhesion, Cell, vol. 69, pp. 11-25 (1992).
Johansson, Mats W., et al., Altered Localization and Cytoplasmic Domain-binding Properties of Tyrosine-phosphorylated .beta..sub.1 Integrin, Journal of Cell Biology, vol. 126, pp. 1299-1309 (1994).
Juliano, R.L. and Haskill, S., Signal Transduction from the Extracellular Matrix, Journal of Cell Biology, vol. 120, pp. 577-585 (1993).
Kieffer, Nelly., et al., Adhesive Properties of the .beta..sub.3 Integrins: Comparison of GP IIB-IIIa and the Vitronectin Receptor Individually Expressed in Human Melanoma Cells, Journal of Cell Biology, vol. 113, pp. 451-461 (1991).
Knezevic I., et al., Direct Binding of the Platelet Integrin .alpha..sub.IIb .beta..sub.3 (GPIIb-IIIa) to Talin, Journal of Biological Chemistry, vol. 271, pp. 16416-16421 (1996).
Kolanus et al., .alpha.L.beta.2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule, Cell, vol. 86, pp. 233-242 (1996).
LaFlamme, Susan E., et al., Single Subunit Chimeric Integrins as Mimics and Inhibitors of Endogenous Integrin Functions in Receptor Localization, Cell Spreading and Migration, and Matrix Assembly, Journal of Cell Biology, vol. 126, No. 5, pp. 12
Li Shengfeng
Phillips David R.
Chan Christina Y.
COR Therapeutics Inc.
Gambel Phillip
LandOfFree
Bap-1 proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bap-1 proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bap-1 proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1066258