Surgery – Respiratory method or device – Ozone or ion generation
Patent
1976-09-07
1977-06-28
Medbery, Aldrich F.
Surgery
Respiratory method or device
Ozone or ion generation
128296, 424267, A61F 702, A61L 1506
Patent
active
040318940
ABSTRACT:
Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 .mu.g/cm.sup.2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 .mu.g/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.
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Lancet Aug. 1, 1970-"Intramuscular Hyoscine in Control of Motion Sickness" pp. 232-234.
Journal of Investigative Dermatology-vol. 43, 1964, pp. 363-377.
"The Antiperspirant Action of Topically Applied Anticholinergics" pp. 128-268.
Aerospace Medicine, vol. 3, No. 3, Mar. 1972, pp. 249-252, "Theory of Antimotion Sickness Drug Mechanisms" Wood & Graybiel.
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"A Theory of Motion Sickness Based on Pharmacological Reactions" pp. 128-268.
Chandrasekaran Santosh Kumar
Shaw Jane Elizabeth
Urquhart John
ALZA Corporation
Ciotti Thomas E.
Mandell Edward L.
Medbery Aldrich F.
Sabatine Paul L.
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