Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1995-08-08
1998-05-05
McDermott, Corrine M.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604131, 604248, A61M 2900
Patent
active
057467170
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a device for the isolated perfusion of therapeutically active substances or substance combinations. The core of the invention is in this case a multi-lumen catheter which is used for the complete or partial blocking of the blood stream of the area of the body to be treated. This interruption or reduction of the flow in a blood vessel permits the administration of locally very high concentrations of active substance which cannot be achieved with conventional techniques without harming the patient.
The administration of such high concentrations of pharmacologically active substances is a requirement which is frequently encountered in medicine. Devices which permit this are desirable in particular in the area of chemotherapy.
Such a device, and an associated double-lumen catheter, are known from DE-A-3,400,874. This publication deals specifically with a double-lumen catheter for a device for in vivo purification of blood, to which device the catheter is attached. The device comprises a peristaltic pump, an ultrafiltration filter and a possibility of introducing anticoagulant into the system. A section of the tube system is guided through a heating bath in order to be able to compensate for temperature losses of the blood. The double-lumen catheter has an open tip communicating with one lumen. The first lumen and a second lumen communicate with lateral openings in the catheter wall.
Multi-lumen balloon catheters of varying design belong to the state of the art.
A multi-lumen balloon catheter with a closed tip is known from U.S. Pat. No. 4,382,688, having, at a short distance from the proximal end of the catheter, an expandable balloon communicating with one catheter lumen. On the proximal side of the balloon, in the catheter wall, there is a lateral opening which communicates with a second catheter lumen. At the rear end the catheter has an attachment piece in order to be able to establish connections with the individual lumina. The catheter can also have several balloons, lateral openings then being present in each case between two balloons.
In DE-A-3,821,544 a balloon catheter is described, the expandable balloon of which has a plurality of pore-shaped through-holes, so that material present inside the balloon can escape upon dilation. This material should exert its action in the area of the contact surface of the balloon with the vessel wall.
A further multi-lumen balloon catheter for drainage purposes is known from U.S. Pat. No. 3,394,705. The catheter has lateral openings both between the tip and the balloon, and also on the proximal side of the balloon, which lateral openings communicate with catheter lumina.
2. Description of the Related Art
In the treatment of tumours the action of cytostatic agents used depends on the local concentration and the pH value. The ability of the tumour cell to form colonies drops sharply in a concentration range of around 10 .mu.g/ml. A high efficacy in the inhibition of tumours is therefore only achieved in this range, it being possible to achieve a further significant increase in the action of the cytostatic agent by means of a still higher concentration, up to a maximum of approximately 100 .mu.g/ml.
In conventional systemic chemotherapy, the concentration of cytostatic agents is limited to 1-2 .mu.g/ml. An increase to the abovementioned range in order to achieve a high tumour toxicity is not possible in this method on account of the systemic side-effects which occur.
SUMMARY OF THE INVENTION
The aim of the present invention is to provide a device which permits the administration of locally high concentrations of a therapeutically active substance. In particular, the device should permit the administration of high concentrations of cytostatic agents for chemotherapy in the range of over 10 .mu.g/ml.
This aim is achieved according to the present invention by means of a multi-lumen balloon catheter with a closed tip and an expandable balloon arranged at a short distance from the pro
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patent: 5147334 (1992-09-01), Moss
patent: 5180366 (1993-01-01), Woods
patent: 5295961 (1994-03-01), Niederhauser
Blyveis Deborah B.
McDermott Corrine M.
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