Balanced translocation in comparative hybridization

Details Balanced translocation in comparative hybridization Balanced translocation in comparative hybridization

2005-11-29

2011-12-13

Pohnert, Steven (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S320100, C536S023100

Reexamination Certificate

active

08076074

ABSTRACT:
The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations. Such probes may be complementary to the moving genomic segment which is translocated or may be complementary to the translocation break point.

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