Balanced oncotic pressure fluid

Details Balanced oncotic pressure fluid Balanced oncotic pressure fluid

1980-03-24

1981-12-29

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424127, 424154, 424156, 424180, 424289, A61K 3106, A61K 3114, A61K 3170, A61K 31315

Patent

active

043082556

ABSTRACT:
A balanced oncotic pressure fluid suitable as a dialysate in the treatment of patients suffering from loss of kidney function. The solution comprises on the basis of 1 liter of solution about 200-300 mEq sodium, about 145-215 mEq chloride, about 55-85 mEq bicarbonate or acetate or lactate, and about 2-10% by weight dextran, the ratio of sodium to chloride being about 1.4:1. An example of the above solution contains about 224 mEq sodium, about 164 mEq chloride, about 72 mEq acetate, about 6% by weight dextran, about 2% dextrose, about 7 mg zinc gluconate, about 2 mEq potassium, about 3 mEq calcium, and about 2 mEq magnesium.

REFERENCES:
Chem. Abst., vol. 89 (1978), 48915s.
Physicians' Desk Reference, Quarterly Supplement No. 3, Jul. 1966, p. 31.
Pharmacia, Rheomacrodex (Dextran 40) flow improver, 1968.
J. Jirka & E. Kotkova, Peritoneal Dialysis by Iso-Oncotic Dextran Solution in Anaesthetized Dogs, Intra-Peritoneal Fluid Volume and Protein Concentration in the Irrigation Fluid, 1967, Dialysis and Renal Transplantation. Proc. 4th Conf. (147-145).
Dr. John Bergan, Thrombosis, Symposium, Contemporary Surgery, vol. 14, May 1979 (pp. 80-101).
Alan T. Marty, M.D., & Benjamin W. Zweifach, The High Oncotic Pressure Effects of Dextrans, Arch Surg. vol. 101, Sep. 1970 (pp. 421-424).
Sven-Erik Bergentz, M.D., On bleeding and Clotting Problems in Post-Traumatic States, Critical Care Medicine, 1976, pp. 41-45.
W. C. Shoemaker, M.D., Choice of Replacement Fluids in Shock, Hospital Physician 7/77 (pp. 27-31).

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