Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-07-19
2011-07-19
Rawlings, Stephen (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C530S350000, C536S023100
Reexamination Certificate
active
07982023
ABSTRACT:
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrateC. elegans(BAG-1, BAG-2) and the fission yeastS. pombe(BAG-1A, BAG-1B) and the nucleic acid molecules that encode them.
REFERENCES:
patent: 5539094 (1996-07-01), Reed et al.
patent: 5650491 (1997-07-01), Reed et al.
patent: 5652223 (1997-07-01), Kohn et al.
patent: 6110690 (2000-08-01), Goeddel et al.
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: WO 95/13292 (1995-05-01), None
Ausubel et al.,Current Protocols in Molecular Biology, John Wiley and Sons, New York (1994).
Boehringer Mannheim Biochemicals, 1994 Catalog (No. 1034 731/1006 924), p. 93.
Bowie et al.,Science257:1306-1310 (1990).
Burgess et al., “Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue,”J. Cell. Biol. 111(5 Pt 1):2129-2138 (1990).
Database Genbank, National Center for Biotech. Info., Accession No. G29287, Myers, R.M., Oct. 4, 1996.
Database Genbank, National Center for Biotech. Info., Accession No. G06974, Hudson, T., “Whitehead Institute. MIT Center for Genome Research,” Oct. 19, 1995.
Database Genbank-EST, National Center for Biotech. Info., Accession No. AA693697, Hiller, L. et al. ‘WashU-NCI human EST Project,’ Dec. 16, 1997.
Database Genbank-EST, National Center for Biotech. Info., Accession No. AA456862, NCI—CGAP, ‘National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index,’ Aug. 15, 1997.
Database Genseq, Derwent, Alexandria, Virginia, Accession No. V81267, Otsuka Pharm Co Ltd, “New Bcl-2 interatction protein gene (Bis)—useful for elucidation of the molecular mechanism of apoptosis, and in diagnosis, prevention and treatment of diseases,” Dec. 15, 1998.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. AA693697, Hillier et al., “WashU-NCI human EST project,” Dec. 16, 1997.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. AA456862, NCI—CGAP, “National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index,” Aug. 15, 1997.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. G29287, Myers, Oct. 4, 1996.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. G06974, Hudson, “Whitehead Institute.MIT Center for Genome Research,” Oct. 19, 1995.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. V81267, Otsuka Pharm Co. Ltd., “New Bcl-2 interaction protein gene (Bis)—useful for elucidation of the molecular mechanism of apoptosis, and in diagnosis, prevention and treatment of diseases,” Dec. 15, 1998.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. T19051, Matsubara et al., “Identifying gene signatures in 3′-directed human cDNA library,” Jun. 1, 1995.
Database, Genbank-EST, National Center for Biotech. Info., Accession No. Q90296, La Jolla Cancer Research Foundation, “Human Bcl-2 associated protein BAG-1 cDNA,” May 18, 1995.
Database, Genseq, Derwent, Alexandria, Virginia, Accession No. Q90296, La Jolla Cancer Res Foun. “Human Bcl-2-associated protein BAG-1 cDNA,” May 18, 1995.
Database, Genseq, Derwent, Alexandria, Virginia, Accession No. T19051, Matsubara et al., Identifying gene signatures in 3′-directed human cDNA library, Jun. 1, 1995.
Ellis, “Molecular chaperones: Avoiding the crowd,”Curr. Biol. 7:R531-R533 (1997).
Grunert and Jackson, “The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons,”Embo J. 13:3618-3630 (1994).
Hillier, L., et al., Unpublished, 1997, Database GenBank EST Accession No. AI815738, au43g01.y1 “Schneider fetal brain 00004Homo sapienscDNA clone Image:2517552, 5′similar to TR:075315”.
Höhfeld et al., “GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1,”Embo J. 16:6209-6216 (1997).
Höhfeld et al., “Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle,”Cell83:589-598 (1995).
Huse et al., “Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda,”Science246:1275-1281 (1989).
Innis et al., PCR Protocols—A guide to methods and applications, Academic Press, Inc., pp. 40-41 (1990).
Kozak, “Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6,” Embo J. 16:2482-2492 (1997).
Lazar et al., “Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities,”Mol. Cell. Biol. 8(3):1247-1252 (1988).
Matsuzawa et al., “p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1,”Embo J. 17:2736-2747 (1998).
Minami et al., “Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40,”J. Biol. Chem. 271:19617-19624 (1996).
Nielsen, P.E. et al., “Peptide nucleic acids (PNAs): Potential anti-sense and anti-gene agents,”Anticancer Drug Des. 8:53-63 (1993).
Prapapanich et al., “Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly,”Mol. Cell. Biol. 18:944-952 (1998).
Sambrook et al.,Molecular cloning: A laboratory manual, 2nd Edition, Cold Spring Harbor Laboratory Press, (1989).
Skolnick et al., “From genes to protein structure and function: novel applications of computational approaches in the genomic era,”Trends Biotech. 18:34-39 (2000).
Sudol, “The WW module competes with the SH3 domain?,”TIBS21:161-163 (1996).
Takayama et al., “An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators,”J. Biol. Chem. 274(2):781-786 (1999).
Takayama et al., “BAG-1 modulates the chaperone activity of Hsp70/Hsc70,”Embo J. 16:4887-4896 (1997).
Takayama et al., “Cloning of cDNAs Encoding the Human BAG1 Protein and Localization of the Human BAG1 Gene to Chromosome 9p12,”Genomics35:494-498 (1996).
Takayama et al., “Expression and Location of Hsp70/Hsc-Binding Anti-Apoptotic Protein BAG-1 and Its Variants in Normal Tissues and Tumor Cell Lines,”Canc. Res. 58:3116-3131 (1998).
Takayama, S, Direct Submission, Sep. 3, 1997, Database GenBank Accession No. AF022224, “Homo sapiensBcl-2-binding protein (BAG-1) mRNA, complete cds.” pp. 1-2.
Terada et al., “The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding,”J. Cell. Biol. 139:1089-1095 (1997).
Xie et al., “Acidic pH promotes dimerization of Bcl-2 family proteins,”Biochem. 37:6410-6418 (1998).
Zeiner and Gehring, “A protein that interacts with members of the nuclear hormone receptor family: Identification and cDNA cloning,”Proc. Natl. Acad. Sci. U.S.A. 92:11465-11469 (1995).
Zeiner et al., “Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins,”Embo J. 16:5483-5490 (1997).
Zeiner, M, Direct Submission, Jul. 28, 1994, Database GenBank Accession No. Z35491, “H. sapiensmRNA for novel glucocorticoid receptor-associated protein.”
Reed John C.
Takayama Shinichi
Day Jones
Rawlings Stephen
Sanford-Burnham Medical Research Institute
LandOfFree
Bag proteins and nucleic acid molecules encoding them does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bag proteins and nucleic acid molecules encoding them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bag proteins and nucleic acid molecules encoding them will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2665027