Bacteriostatic dialyzers containing citric acid solutions

Liquid purification or separation – Casing divided by membrane into sections having inlet – Energy recovery from treated liquid

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21032172, 210749, 210764, 422 1, 422 28, B01D 6502, B01D 6506, A61L 216

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active

056981007

ABSTRACT:
A method for reprocessing dialyzer cartridges used with kidney dialysis machines is provided. The method involves filling the blood and dialysate compartments of the dialyzer with an aqueous solution containing citric acid at a concentration of 1.0-5.0 wt. %, e.g., 1.5 wt. %, and then subjecting the dialyzer to an elevated temperature above 90.degree. C. and below 100.degree. C., e.g., 95.degree. C., for a period of at least 15 hours, e.g., 20 hours. Although citric acid is non-toxic and the temperature used is below the boiling point of water, the process has been found to produce a fully sterilized dialyzer. After reprocessing, the aqueous citric acid solution is preferably left in the dialyzer where it acts as a bacteriostatic agent during storage. Essentially no damage to the dialyzer and, in particular, to its semipermeable membrane results from either the reprocessing or storage procedures.

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Kaufman et al., "Clinical Experience with Heat Sterilization for Reprocessing Dialyzers," ASAIO Transactions, vol. 38, No. 3, Jul.-Sep. 1992, pp. M338-M340.

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