Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Virus or bacteriophage
Patent
1996-04-12
1998-09-22
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Virus or bacteriophage
536 2433, 4352351, 435 912, A01N 6300, C07H 2104, C12P 1934, C12N 701
Patent
active
058110933
ABSTRACT:
The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging of a bacteriophage, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
REFERENCES:
H. Williams Smith et al, Journal of General Microbiology, vol. 128, issued 1982, "Successful Treatment of Experimental Escherichia coli Infections in Mice using Phage: its General Superiority over Antibiotics", pp. 307-318.
H. Williams Smith et al, Journal of General Microbiology, vol. 133, issued 1987, "The Control of Experimental Escherichis coli Diarrhoea in Claves by Means of Bacteriophages", pp. 1111-1126.
Adhya Sankar L.
Carlton Richard M.
Merril Carl R.
Chambers Jasemine C.
Clark Deborah J. R.
Exponential Biotherapies, Inc.
The United States of America as represented by the Department of
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