Bactericidal factor in human airway surface fluid and uses there

Details Bactericidal factor in human airway surface fluid and uses there Bactericidal factor in human airway surface fluid and uses there

1997-04-17

1999-08-17

Weber, Jon P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530300, 530324, 514 2, A61K 3800, A61K 3802, A01N 3718

Patent

active

059393939

ABSTRACT:
A bactericidal factor isolated from the surface fluid of airway epithelial cells and uses therefore is described. The bactericidal factor is characterized as having the following features: a) a molecular weight of less than 10 kd; b) heat stable; c) broad spectrum activity including gram positive and gram negative bacteria, fungi, and methicillin resistant Staphylococcus; and d) decreased antimicrobial activity in increasing salt concentration.

REFERENCES:
patent: 5202420 (1993-04-01), Zasloff et al.
patent: 5432270 (1995-07-01), Zasloff et al.
Ellison et al. (1984) Clinical Research, 32(2), "Isolation of an Antibacterial Peptide from Human-Lung Lavage", p. A367.
Ellison et al. (1985) J. Infect. Dis., 151(6), "Isolation of an Antibacterial Peptide from Human Lung Lavage Fluid", pp. 1123-1129.
Diamond et al. (1991) Proc. Nat. Acad. Sci. USA, 88(9), "Tracheal Antimicrobial Peptide, A Crysteine-Rich Peptide from Mammalian Tracheal Mucosa: Peptide Isolation and Cloning of cDNA", pp. 3952-3956.
Diamond et al. (1993) Proc. Nat. Acad. Sci. USA, 90, "Airway Epithelial Cells are the site of Expression of a Mammalian Antimicrobial Peptide Gene", pp. 4596-4600.
Lehrer et al. (1993) Annu. Rev. Immunol., 11, "Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells", pp. 105-128.
Martin et al. (1995) J. Leukocyte Biol., 58(2), "Defensins and Other Endogenous Antibiotics of Vertabrates", pp. 128-136.
Smith et al. (1996) Cell, 85(2), "Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid", pp. 229-236.

Affiliated with

Also associated with

Rating

Bactericidal factor in human airway surface fluid and uses there does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bactericidal factor in human airway surface fluid and uses there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bactericidal factor in human airway surface fluid and uses there will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-314864