Bactericidal compositions and methods

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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Details

424130, 424230, 424258, 424274, 424317, 424319, 424330, 424338, 435 78, 435264, A61K 3748, A61K 3340, A61K 31075, C12P 1956

Patent

active

044735502

ABSTRACT:
Bactericidal compositions and methods include the use of a peroxide and a peroxidase in a defined area such as the mouth to rapidly and efficiently kill bacteria. Donor molecules are transformed into bactericidal free radicals which carry out the desired action. The compositions and methods are particularly effective in alleviating gingival disease and periodontal disease.

REFERENCES:
patent: 959605 (1910-05-01), Queisser
patent: 2527686 (1950-10-01), Sandberg
patent: 2554464 (1951-05-01), Kraus
patent: 3829329 (1974-08-01), O'Driscoll et al.
patent: 4150113 (1979-04-01), Hoogendoorn et al.
patent: 4154815 (1979-05-01), Pader
patent: 4178362 (1979-12-01), Hoogendoorn et al.
patent: 4269822 (1981-05-01), Pellio et al.
"Enzymes", Dixon et al., Academic Press Inc., N.Y., 1958, pp. 100-104 & 208.
Elliott, K. A. C., Oxidations Catalysed by Horseradish & Milk Peroxidases, Biochm. J. 26, 1281-1290, (1932).
Sizer, I. W., The Oxidative Inactivation of Poison Ivy Allergens, by Peroxidase, J. Invest. Dermatology, 16, 103-110, (1951).
Wennstrom et al., Effect of Hydrogen Peroxide on Developing Plaque and Gingivitismman; J. Clinical Period, 6, 115-130, (1979).

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