Bacterial vaccines using vaccine strains of pathogenic bacteria

Details Bacterial vaccines using vaccine strains of pathogenic bacteria Bacterial vaccines using vaccine strains of pathogenic bacteria

1995-04-07

1998-05-05

Minnifield, Nita

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351721, 435243, 4352528, 4241841, 4242341, 4242411, 4242571, 424 934, C12N 1500, C12N 100, C12N 120, A61K 39108

Patent

active

057473099

ABSTRACT:
Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods. In particular, pathogenic bacteria comprising at least one attenuating mutation selected from the group consisting of a pyrimidine pathway mutation, an iron metabolism mutation, and a colicin transport mutation which retain their immunogenicity so as to provide protective immunity are provided.

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