Bacterial toxoids and gram-negative immune globulin therefrom

Details Bacterial toxoids and gram-negative immune globulin therefrom Bacterial toxoids and gram-negative immune globulin therefrom

1982-03-15

1984-01-31

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 424 85, 424 88, 260112R, 536 26, A61K 3905, A61K 39108, C07C10352

Patent

active

044289316

ABSTRACT:
ADP-ribosylating toxins are rendered exzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins. These bacterial toxoids can be used as immunogens to protect against the specific disease that the precursor toxins cause or, in the case of P. aeruginosa, the toxiod can be used in combination with E. coli J-5 vaccine to protect against gram-negative bacteremia in general.

REFERENCES:
patent: 4053584 (1977-10-01), Doberscu et al.
patent: 4136181 (1979-01-01), Dobrescu et al.
patent: 4157389 (1979-06-01), Homma et al.
Braude et al., Schweiz. Med. Wschr. 108, pp. 1872-1876 (1978), Antiserum Treatment of Gram-Negative Bacteremia.
Cryz et al. Infection & Immunity, May 1981- pp. 759-768, Effect of Formalin Toxoiding on Pseudomonas, Aeruginosa Toxin A: Biological, Chemical, and Immunochemical Studies, pp. 759-768.
Schmidt et al. FEBS Letters, vol. 129, No. 2, pp. 306-308, 8-Azidoadenine: A Photoaffinity Label for the Purine Transport System in Saacharomyces cerevisiae.
Rappaport et al., Infection & Immunity May 1981--pp. 534-541, Development of a Vaccine Against Experimental Cholera and Escherichia coli Diarrheal disease.

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