Bacterial toxoids and gram-negative immune globulin therefrom

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424 92, 424 87, 536 26, C07G 700, A61K 39104

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active

044889917

ABSTRACT:
ADP-Ribosylating toxins are rendered enzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins. These bacterial toxoids can be used as immunogens to protect against the specific disease that the precursor toxins cause or, in the case of P. aeruginosa, the toxoid can be used in combination with E. coli J-5 vaccine to protect against gram-negative bacteremia in general.

REFERENCES:
Chemical Abstracts, vol. 96, Abstract No. 3255e, 1982.
Proc. Natl. Aca. Sci. USA, vol. 80, pp. 2870-2873, May 1983, Biochemistry-Pseudomonas Exotoxin A: Toxoid Preparation by Photoaffinity Inactivation, S. Marburg, R. L. Tolman, and L. T. Callahan III.
Infection and Immunity, Mar. 1984, pp. 1019-1026, vol. 43, No. 3; Toxoids of Pseudomonas Aeruginosa Exotoxin-A: Photoaffinity Inactivation of Purified Toxin and Purified Toxin Derivatives-L. T. Callahan III, D. Martinez, S. Marburg, R. L. Tolman, and D. R. Galloway.
Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 3307-3311, Jun. 1984.

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