Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-10-26
1984-12-18
Hazel, Blondel
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424 92, 424 87, 536 26, C07G 700, A61K 39104
Patent
active
044889917
ABSTRACT:
ADP-Ribosylating toxins are rendered enzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins. These bacterial toxoids can be used as immunogens to protect against the specific disease that the precursor toxins cause or, in the case of P. aeruginosa, the toxoid can be used in combination with E. coli J-5 vaccine to protect against gram-negative bacteremia in general.
REFERENCES:
Chemical Abstracts, vol. 96, Abstract No. 3255e, 1982.
Proc. Natl. Aca. Sci. USA, vol. 80, pp. 2870-2873, May 1983, Biochemistry-Pseudomonas Exotoxin A: Toxoid Preparation by Photoaffinity Inactivation, S. Marburg, R. L. Tolman, and L. T. Callahan III.
Infection and Immunity, Mar. 1984, pp. 1019-1026, vol. 43, No. 3; Toxoids of Pseudomonas Aeruginosa Exotoxin-A: Photoaffinity Inactivation of Purified Toxin and Purified Toxin Derivatives-L. T. Callahan III, D. Martinez, S. Marburg, R. L. Tolman, and D. R. Galloway.
Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 3307-3311, Jun. 1984.
Callahan, III Lynn T.
Marburg Stephen
Tolman Richard L.
Elder Richard A.
Hazel Blondel
Lopez Gabriel
Merck & Co. , Inc.
Pfeiffer Hesna J.
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