Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2000-08-23
2008-08-12
Prouty, Rebecca E. (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S320100, C435S252300, C435S220000, C435S325000, C536S023200
Reexamination Certificate
active
07410638
ABSTRACT:
The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting of104HXHXDH109˜60aa˜H169˜21aa˜D191and103HXHXDH108˜72aa˜H180˜21aa˜D202, and to expression vectors and transformed plant and animal cells comprising the same. The proteins encoded by these nucleic acid molecules provide to a susceptible plant or animal increased resistance to a disease the virulence of which is regulated by autoinducers. Also provided are methods of increasing disease resistance in susceptible plants and animals.
REFERENCES:
Matthysse A. G. et al. A region of theAgrobacterium tumefacienschromosome containing genes required for virulence and attachment to host cells, Biochem. Biophys. Acta, 1490, 208, 212, Jan. 31, 2000.
GenBank Accession No. Q9WWD3, created Nov. 1, 1999.
Dong Yi-Hu et al. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence ofErwinia carotovora,Proc. Natl. Acad. Sci. USA, 97, 3526-3531, Mar. 28, 2000.
Mathysse A.G. Characterisation of Nonattaching Mutants ofAgrobacterium tumefaciens,J. Bacteriol. 169, 313-323, 1997.
Dong Yihu
Xu Jinling
Zhang Haibao
Zhang Lianhui
Institute of Molecular Agrobiology
Prouty Rebecca E.
Rothwell Figg Ernst & Manbeck P.C.
Walicka Malgorzata A.
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