Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1995-03-10
1998-09-01
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 9341, 424 9346, 4242341, 4242461, 4242471, A61K 3902
Patent
active
058008217
ABSTRACT:
A method of stimulating a vertebrate animal to produce an immune response to at least one antigen is described. The method includes genetically engineering a bacterial cell with DNA encoding at least one antigen and inducing the bacterial cell to sporulate, then orally administering the bacterial spores to an animal. The bacterial spores germinate in the gastrointestinal tract of the animal and express the antigen so that it comes into contact with the animal's immune system and elicits an immune response.
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Acheson David W. K.
Keusch Gerald T.
Sonenshein Abraham L.
Housel James C.
New England Medical Center Hospitals Inc.
Shaver Jennifer
Trustees of Tufts College
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