Bacterial protein phosphoinositide probes and effectors

Details Bacterial protein phosphoinositide probes and effectors Bacterial protein phosphoinositide probes and effectors

2006-09-23

2009-12-08

Blanchard, David J (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007700, C436S513000, C436S518000, C436S543000, C436S546000

Reexamination Certificate

active

07629130

ABSTRACT:
Methods for detecting and quantifying phosphoinositide lipids in a sample are provided, together with novel SidC- and SdcA-derived polypeptide fragments, or fusion proteins comprising such fragments that may be effectively employed as PI(4)P probes in biochemical and cell biological assays. Applications of the disclosed probes include: (i) detection and quantification of PI(4)P in vitro; and (ii) staining of intracellular compartments in live or fixed eukaryotic cells.

REFERENCES:
Bowie et al. Science vol. 247, No. 4948, p. 1306-1310,1990.
Lazar et al. Molecular and Cellular Biology, Mar. 1988, p. 1247-1252.
Burgess et al. The Journal of Cell Biology, vol. 111, Nov. 1990 2129-2138.
Bork (Genome Research, 2000,10:398-400).
Weber, Stefan S. et al., “Legionella pneumophilaExploits (PI(4)P to Anchor Secreted Effector Proteins to the Replicative Vacuole,” PLoS Pathogens, www.plospathogens.org., vol. 2, Issue 5, pp. 0001 to 0013 (May 2006).

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