Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-05-15
1993-08-17
Weimar, Elizabeth C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530825, 530402, 53038825, 530381, C07K 1500, A61K 3900
Patent
active
052370500
ABSTRACT:
The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and expressed. This receptor can be used in combination therapies where it is administered prior to, concurrently with, or after a plasminogen activator. Also, this receptor can be bound to plasmin and administered to humans or animals in need of fibrinolytic activity. Additionally, the invention pertains to a novel immobilized form of plasmin which advantageously accumulates at the point where antifibrinolytic activity is needed.
REFERENCES:
Sevilla et al. BBRC 130(1): 91. 1985.
Broeseker et al (Microb. Pathog 5(1):19. 1988) CIAS Abstract 110:55244.
Broder et al. JBC 266(8): 4922. 1991.
Broder, C. C. Dissentation Abstracts 51/03-B: p. 1105. 1989.
Lotteoberg et al Infection and Immunity 55(8): pp. 1914-1928. 1987.
Sevilla et al. BBRC 130(1): 91. 1985.
Boyle Michael D. P.
Broder Christopher
Lottenberg Richard
Von Mering Gregory
University of Florida Research Foundation Inc.
Weimar Elizabeth C.
Ziska Suzanne
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