Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-07-11
2000-10-24
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4241851, 4241901, 4242441, 530350, A61K 3900, A61K 3902, A61K 3909, C07K 100
Patent
active
061363235
ABSTRACT:
The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and expressed. This receptor can be used in combination therapies where it is administered prior to, concurrently with, or after a plasminogen activator. Also, this receptor can be bound to plasmin and administered to humans or animals in need of fibrinolytic activity. Additionally, the invention pertains to a novel immobilized form of plasmin which advantageously accumulates at the point where antifibrinolytic activity is needed.
REFERENCES:
patent: 5476657 (1995-12-01), Potter
Sher et al, Parasitology 98: 561-568, 1989.
Waine et al. Infection and Immunity 61 (11): 4716-4723, 1993.
Bisno, New England Journal of Medicine 325 (11): 783-793, 1991.
Broder, Christopher, Dissertation, University of Florida, 1989.
Von Mering et al. Clinical Research 36 (3): 464A, 1988.
Lottenberg, R. et al. (1987) "Identification of a Specific Receptor for Plasmin on a Group A Streptococcus" Infection and Immunity 55(8):1914-1918.
Bisno, A.L. (1991) "Group A Streptococcal Infections and Acute Rheumatic Fever" The New England Journal of Medicine 325(11):783-793.
Siefring, G.E., F.J. Castellino (1976) "Interaction of Streptokinase with Plasminogen" The Journal of Biologic Chemistry 251 (13):3913-3920.
L.A. Liotta et al. (1981) "Effect of Plasminogen Activator (Urokinase), Plasmin, and Thrombin on Glycoprotein and Collagenous Components of Basement Membrane" Cancer Research 41:4629-4636.
Broeseker, T.A. et al. (1988) "Characterization of the Interaction of human plasmin with its specific receptor on a group A streptococcus" Microbial Pathogenesis 5:19-27.
DesJardin, L.E. et al. (1989) "Group A Streptococci Bind Human Plasmin but not Other Structurally Related Proteins" Thrombosis Research 55:187-193.
Alefounder, P.R., R.N. Perham (1989) "Identification, molecular cloning and sequence analysis of a gene cluster encoding the Class II fructose 1,6-bisphosphate aldolase, 3-phospoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrpgenase of Escherichia coli" Molecular Microbiology 3(6):723-732.
Holland, J.P. et al. (1983) "Homologous Nucleotide Sequences at the 5' Termini of Messenger RNAs Synthesixed from the Yeast Enolase and Glyceraldehyde-3-phosphate Dhydrogenase Gene Families" The Journal of Biological Chemistry 258(8):5291-5299.
P.A.M. Michels et al. (1991) "The cytosolic and glycosomal isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei have a distant evolutionary relationship" Eur. J. Biochem. 198:421-428.
J.Y. Tso et al. (1985) "Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene" Nucliec Acids Research 13(7):2485-2502.
Lambeir, A.-M. et al. (1991) "The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei" Eur. J. Biochem 198:429-435.
Allen, R.W. et al. (1987) "Identification of the 37-kDa Protein Displaying a Variable Interaction with the Erythroid Cell Membrane as Glyceraldehyde-3-phosphate Dehydrogenase" The Journal of Biological Chemistry 262(2):649-653.
Goudot-Crozel, V. et al. (1989) "The Major Parasite Surface Antigen Associated with Human Resistance to Schistosomiasis is a 37-kD Glyceraldehyde-3P-Dehydrogenase" J. Exp. Med. 170:2065-2080.
Allen, R.W., B.A. Hoover (1985) "Characterization of the Processed Form of a Ubiquitous Protein Displaying a Variable Membrane Organization in Erythroid Cells" Blood 65(5):1048-1055.
Blobel, G. (1980) "Intracellular protein topogenesis" Proc. Natl. Acad. Sci. USA 77(3):1496-1500.
Ferguson, M.A.J., A.F. Williams (1988) "Cell-Surface Anchoring of Proteins via Glycosylphosphatidylinositol Structures" Ann. Rev. Biochem. 57:285-320.
Hekman, W.E. et al. (1990) "Secretion of Ricinus communis glyceraldehyde-3-phosphate dehydrogenase by Escherichia coli" Molecular Microbiology 4(8):1363-1369.
Pancholi, V., V.A. Fischetti (1992) "A Novel Multifunctional Surface Protein (MF6) of group A" Abstracts of the General Meeting-1992, abstract No. B252.
Boyle Michael D. P.
Broder Christopher
Lottenberg Richard
Von Mering Gregory
Housel James C.
Ryan V.
University of Florida Research Foundation Inc.
LandOfFree
Bacterial plasmin receptors as fibrinolytic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bacterial plasmin receptors as fibrinolytic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bacterial plasmin receptors as fibrinolytic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960664