Bacterial peptide methionine sulfoxide reductase, and adhesion-a

Details Bacterial peptide methionine sulfoxide reductase, and adhesion-a Bacterial peptide methionine sulfoxide reductase, and adhesion-a

1997-08-20

1998-08-25

Grimes, Eric

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

530350, 536 232, 536 237, 435 691, 4352523, 4353201, C12N 902, C07K 100, C07H 2104, C12P 2106

Patent

active

057982430

ABSTRACT:
The present invention relates to the identification of a bacterial adhesion associated protein, and the gene encoding such protein. More particularly, the invention relates to a pneumococcal peptide methionine sulfoxide reductase involved in bacterial adherence. The invention also relates to identification and development of agents to provide protection from bacterial infection based on this protein. The invention provides nucleic acids encoding the peptide methionine sulfoxide reductase, as well as methods for identifying antagonists of the methionine sulfoxide reductase. The present invention further demonstrates that peptide methionine sulfoxide reductase is an adhesion-associated protein in various Gram-negative and Gram-positive bacteria and accordingly provides for interference with the peptide methionine sulfoxide reductase to inhibit bacterial adherence to host tissues.

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