Bacterial nitroreductase for the reduction of CB 1954 and analog

Details Bacterial nitroreductase for the reduction of CB 1954 and analog Bacterial nitroreductase for the reduction of CB 1954 and analog

1995-06-07

1998-07-14

Ambrose, Michael G.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

536 64, 548422, 558272, 558275, 560 30, 560 32, 560163, C07K 756, C07H 1524, C07D48714, C07C27128, C07C26904, C07C 6996, C07C 6800

Patent

active

057805857

ABSTRACT:
A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R--NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.1 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

REFERENCES:
patent: 4472312 (1984-09-01), Anathasubramanian et al.
patent: 4617398 (1986-10-01), Bardos et al.
patent: 4680382 (1987-07-01), Sengupta
patent: 4868303 (1989-09-01), Takase et al.
Bryant, Christopher et al., "Cloning, Nucleotide Sequence, and Expression of the Nitroreductase Gene from Enterobacter cloacae", Journal of Biological Chemistry, vol. 266, No. 7, pp. 4126-4130 (Mar. 1991).
Bryant, D.W. et al., "Type I Nitroreductases of Escherichia coli", Canadian Journal of Microbiology, vol. 27, pp. 81-86 (1981).
Narai, Noriko et al., "A Comparative Study on 1-Nitro-pyrene and Nitrofurazone Reductases in Escherichia Coli" J. Pharm. Dyn., vol. 7, pp. 407-413 (1984).
Doi, Takayoshi et al., "Properties of Nitrofuran Reductases from Escherichia coliB/r", Chem.Pharm.Bull., vol. 31, pp. 1105-1107 (1983).
Chemical Abstracts, vol. 95, Abstract No. 98201a (1981), Mikhailopulo, I.A. et al., "Synthesis of glycosides on nicotinamide and nicotinamide mononucleotide."
Knox, Richard J., "A New Cytotoxic, DNA Interstrand Crosslinking Agent, 5-(Aziridin-1-YL)-4-Hydroxylamino-2-Nitrobenzamide, is Formed From 5-(Azirdin-1-YL)-2,4-Dinitrobenzamide (CB 1954) by a Nitroreductase Enzyme in Walker Carcinoma Cells", Biochemical Pharmacology, vol. 37, No. 24, pp. 4661-4669 (1988).

Affiliated with

Also associated with

Rating

Bacterial nitroreductase for the reduction of CB 1954 and analog does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bacterial nitroreductase for the reduction of CB 1954 and analog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bacterial nitroreductase for the reduction of CB 1954 and analog will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1882752