Bacterial nitric oxide synthases and uses thereof

Details Bacterial nitric oxide synthases and uses thereof Bacterial nitric oxide synthases and uses thereof

2007-04-24

2007-04-24

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S006120, C435S069100, C435S320100, C435S325000, C435S252300, C435S254200, C435S254110, C435S348000, C435S252310, C435S252320, C435S252330, C435S252350, C435S254210, C435S254300, C435S254500, C435S419000, C536S023200

Reexamination Certificate

active

10858706

ABSTRACT:
The present invention relates to isolated nucleic acid molecules encoding nitric oxide synthases. The isolated nucleic acid molecules and their encoded protein or polypeptides are useful in methods for attaching a nitrogen group to a target moiety of a compound and for synthesizing a nitrogen-modified compound in a transgenic host cell. The present invention also relates to expression systems and host cells containing the nucleic acids of the present invention, as well as a method of recombinantly producing the nitric oxide synthases of the present invention.

REFERENCES:
Adak et al., “Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein fromBacillus subtilis,” J. Biol. Chem.277 (18):16167-16171 (2002).
Alderton et al., “Nitric Oxide Synthases: Structure, Function and Inhibition,”Biochem. J. 357:593-615 (2001).
Alvarez et al., “Peroxynitrite-Dependent Tryptophan Nitration,”Chem. Res. Toxicol. 9:390-396 (1996).
Carter et al., “Direct Biochemical Nitration in the Biosynthesis of Dioxapyrrolomycin. A Unique Mechanism for the Introduction of Nitro Groups in Microbial Products,”J. Chem. Soc., Chem. Commun. 17:1271-1273 (1989).
GenBank Accession No. AAC52356 (Jan. 17, 1996).
GenBank Accession No. AAP29327 (Apr. 30, 2003).
GenBank Accession No. AAP12306 (May 16, 2003).
GenBank Accession No. AE016749 (Jan. 1, 2003).
GenBank Accession No. AE002088 (Nov. 22, 1999).
GenBank Accession No. AY204507 (May 7, 2004).
GenBank Accession No. AY204508 (May 7, 2004).
GenBank Accession No. AY204509 (May 7, 2004).
GenBank Accession No. AAO53225 (May 7, 2004).
GenBank Accession No. AAO53226 (May 7, 2004).
GenBank Accession No. AAO53227 (May 7, 2004).
GenBank Accession No. BAB04542 (Dec. 1, 2004).
GenBank Accession No. BAB95720 (Nov. 30, 2004).
GenBank Accession No. BAC69241 (Oct. 29, 2004).
GenBank Accession No. CAB12592 (Jul. 7, 2003).
Healy et al., “Involvement of a Cytochrome P450 Monooxygenase in Thaxtomin A Biosynthesis byStreptomyces acidiscabies,” J. Bacteriology184(7):2019-2029 (2002).
Hughes, M.N., “Relationships Between Nitric Oxide, Nitroxyl Ion, Nitrosonium Cation and Peroxynitrite,”Biochim. Biophys. Acta1411:263-272 (1999).
Jalal et al., “Structure of Anticancer Antibiotic L-Alanosine,”Acta Cryst. C42:733-738 (1986).
Kers et al., “Nitration of a Peptide Phytotoxin by Bacterial Nitric Oxide Synthase,”Nature429(6987)79-82 (2004).
Koppenol, W.H., “The Basic Chemistry of Nitrogen Monoxide and Peroxynitrite,”Free Radic. Biol. Med. 25(4-5):385-391 (1998).
Ohba et al., “Nitropeptin, A New Dipeptide Antibiotic Possessing a Nitro Group,”J. Antibiot. 40(5):709-713 (1987).
Pant et al., “Structure of a Nitric Oxide Synthase Heme Protein fromBacillus subtilis,” Biochemistry41:11071-11079 (2002).
Patel et al., “Biological Aspects of Reactive Nitrogen Species,”Biochim. Biophys. Acta1411(2-3):385-400 (1999).
Ridd, J.W., “Some Unconventional Pathways in Aromatic Nitration,”Acta Chemica. Scand. 52:11-22 (1998).

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