Bacterial mass production of taxanes with Erwinia

Details Bacterial mass production of taxanes with Erwinia Bacterial mass production of taxanes with Erwinia

1995-05-05

1996-10-01

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435123, 435 34, 549510, 549511, C12N 120, C12P 1702

Patent

active

055610552

ABSTRACT:
The present invention relates to a biologically pure culture of a novel bacteria of genus Erwinia, which is isolated from Taxus canadensis, and wherein said bacteria of genus Erwinia is characterized by the production of paclitaxel and related taxanes in a fermentative or respiratory type of metabolism from simple semi-synthetic or synthetic culture media. Also, the present invention relates to a method of bacterial mass production of paclitaxel and related taxanes which comprises the steps of: a) culturing the bacteria of genus Erwinia of the present invention in a growth-supporting nutrient medium capable of promoting growth and reproduction of said bacteria, and wherein said culturing is effected for a time sufficient to allow production of paclitaxel and related taxanes; and b) isolating said produced paclitaxel and related taxanes from said culturing medium of step a).

REFERENCES:
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Forastiere AA et al., Sep. 23-24, 1992, Proceedings of the Second National Cancer Institute Workshop on Taxol and Taxus (abstrc.), Alexandria, VA:181-184.
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