Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-02-27
2007-02-27
Navarro, Mark (Department: 1645)
Chemistry: molecular biology and microbiology
Vector, per se
Reexamination Certificate
active
10856409
ABSTRACT:
The present invention relates to a nucleic acid sequence and its corresponding protein sequence useful as a dominant selectable marker in eukaryotes. More specifically the invention relates to a nucleic acid encoding a bacterial IMPDH gene that has been engineered into a eukaryotic expression vectors, thereby permitting bacterial IMPDH expression in mammalian cells. Bacterial IMPDH expression confers resistance to MPA which can be used as dominant selectable marker in eukaryotes including mammals. The invention also relates to expression vectors and cells that express the bacterial IMPDH gene as well as gene therapies and protein synthesis.
REFERENCES:
patent: 6153398 (2000-11-01), Collart et al.
patent: 6479628 (2002-11-01), Collart et al.
patent: 2005/0202520 (2005-09-01), Dorn et al.
Mekhine Baccam et al.Bacterial IMPDH Geme Used for Selection of Mammalian Cell Transfectants. BioTechniques. 34:1220-1230 (Jun. 2003).
Baccam Mekhine J.
Huberman Eliezer
Dobbs Michael J.
Gottlieb Paul A.
Lally Brian J.
Navarro Mark
The United States of America as represented by the United States
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