Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1997-12-15
2000-09-26
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242501, 4241841, 530350, 530825, A61K 3902, A61K 39095, A61K 3900, C07K 100
Patent
active
061239429
ABSTRACT:
The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of a bacterial hemoglobin receptor protein, nucleic acid encoding such a protein, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effectinve in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: B14683202 (1990-11-01), Mullis et al.
Archibald and DeVoe, (1979) FEMS Mirocbiol. Lett., 6, pp. 159-162.
Baggs and Neilands, (1991), Mircrobiol. Rev., 51, 509-518.
Braun and Hantke, (1991) in Winkelman (ed.) Handbook of Microbial Iron Chelates, pp. 107-138.
Calver et al., (1976) Can. J. Microbiol., 22, 832-838.
Cornelissen et al., (1993) J. Bacteriol., 174: pp. 5788-5797.
Correia et al., (1988) J. Biol. Chem., 263: 12194-12198.
Coulton and Pang, (1983) Curr. Microbiol., 9: pp. 93-98.
Dyer et al., (1987) Infect. Immun., 55: pp. 2171-275.
Fenno et al., (1993) Gene, 130: 81-90.
Gerlach et al., (1992) Infect. Immun., 60: 3253-3261.
Gotschlich et al., (1987) J. Exp. Med., 165: pp. 471-482.
Hames and Higgins, eds., (1985) Nucleic Acid Hybridization.
Harlow and Lane, (1988) Antibodis: A Laboratory Manual.
Heller et al., (1988) Gene, 64: pp. 147-153.
Henderson and Payne, (1994) J. Bacteriol, 176: pp. 3269-3277.
Hnatowich et al., (1983) Science, 220: pp. 613-615.
Holbien et al., (1981) Infect. Immun., 34: 120-125.
Jarosik et al., (1994) Infect. Immun., 62: pp. 2470-2477.
Kellog et al., (1963) J. Bacteriol, 85: 1274-1279.
Knight et al., (1992) Mol. Microbiol., 6: pp. 1565-1573.
Koebnik et al., (1993) Trends Microbiol., 6: pp. 1565-1573.
Lee and Hll, (1992) J. Gen. Microbiol., 138: 2647-2656.
Lee, (1994) Microbiol., 140: 1473-1480.
Lundrigan & Kadner, (1986) J. Biol. Chem., 261: pp. 10797-10801.
Martek and Lee, (1994) Infect. Immun., 62: 700-703.
McConville and Charles, (1979) J. Microbiol., 113: 165-168.
Meares et al., (1984) Anal. Biochem., 142: 68-78.
Mickelson et al., (1982) Infect. Immun., 35: pp. 915-920.
Nassif et al., (1993) Mol. Microbiol., 6: pp. 719-725.
Otto et al., (1992) Crit. Rev. Microbiol., 18: 217-233.
Pettersson et al., (1994) J. Bacteriol., 176: pp. 1764-1766.
Pettersson et al., (1993) Infect. Immun., 61: 4724-4733.
Postle, (1990) Mol. Microbiol., 133: pp. 891-898.
Riboli et al., (1991) Microb. Pathogen., 10: pp. 393-403.
Saiki et al., (1988) Science, 230: 1350-1354.
Sambrook et al., (1989) Molecular Clonong: A Laboratory Manual.
Schoffler and Braun, Molec. Gen. Genet., 217: pp. 378-383.
Schryvers and Morris, (1988) Infect. Immun., 56: pp. 1144-1149.
Schryvers and Morris, (1988) Mol. Microbiol., 2: 281-288.
Schryvers et al., (1989) Infect. Immun., 57(8): pp. 2425-2429.
Stojiljkovic et al., (1992) EMBO J., 11: pp. 4359-4367.
Stroebner and Payne, (1988) Infec. Immun., 56: pp. 2891-2895.
Struyve et al., (1991) J. Mol. Biol., 218: 141-148.
Walters, (1993) Pharmaceutical Biotechnology, pp. 165-174.
Weinberg. (1984) Physiological Rev., 64: pp. 65-102.
West and Sparling, (1985) Infect. Immun., 47: pp. 288-294.
Rudinger, (Jun. 1976), Peptide Hormones, pp. 1-7.
Stojiljkovic et al., (1995) Mol. Microbiol., 15: pp. 531-541.
Legrain et al., (1993) Gene, 130: pp. 81-90.
Bittner et al., (1995), Abstract Of The General Meeting Of The American Society For Microbiology, vol. 95, p. 227.
Heffron Fred
Hwa Vivian
Nassif Xavier
So Magdalene
Stojiljkovic Igor
Devi S.
Housel James C.
Oregon Health & Sciences University
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