Bacterial hemoglobin receptor gene

Details Bacterial hemoglobin receptor gene Bacterial hemoglobin receptor gene

1994-10-18

1997-12-16

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 237, C12N 121, C12N 1574, C12N 1531

Patent

active

056984383

ABSTRACT:
The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of a bacterial hemoglobin receptor protein, nucleic acid encoding such a protein, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effective in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.

REFERENCES:
Martek & Lee, 1994, "Acquisition of Heme Iron by Neisseria meningitidis Does not Involve Meningococcal Transferrin-Binding Proteins," Infect. Immunol. 62: 700-703.

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