Bacterial exported proteins and acellular vaccines based thereon

Details Bacterial exported proteins and acellular vaccines based thereon Bacterial exported proteins and acellular vaccines based thereon

1994-05-18

1999-07-27

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4241851, 4241901, 4242441, 530350, C12P 2106, A61K 3900, A61K 3902, C07K 100

Patent

active

059289007

ABSTRACT:
The present invention relates to the identification of Gram positive bacterial exported proteins, and the genes encoding such proteins. In particular, the invention relates to adhesion associated exported proteins, and to antigens common to many or all strains of a species of Gram positive bacterium. The invention also relates to acellular vaccines to provide protection from Gram positive bacterial infection using such genes or such proteins, and to antibodies against such proteins for use in diagnosis and passive immune therapy. In specific embodiments, fragments of ten genes encoding exported proteins of S. pneumoniae are disclosed, and the functional activity of some of these proteins in adherence is demonstrated.

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